Galenical formulation for oral administration, method for the preparation thereof and use of absorption-promoting agent in the preparation thereof

摘要

Galenical formulation for oral administration allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active ingredients, comprising a) metformin or its pharmaceutically acceptable salt, especially its hydrochloride, b) an absorption-promoting agent having an HLB greater than 8 which is one or more lipid substance selected from polysorbates, ethers of polyoxyethylene and alkyl, esters of polyoxyethylene and fatty acids, fatty acids, fatty alcohols, bile acids and their salts with pharmaceutically acceptable cations, esters of C1-C6 alkanols with fatty acids, esters of polyol with fatty acids, whereby the polyol comprises from 2 to 6 hydroxyl functional groups and polyglycolysed glycerides, and c) one or more pharmaceutically acceptable excipients.