DERIVATIVES OF BENZOTIAZOL- AND BENZOXAZOL-4,7-DIONA AND ITS USE AS CDC25 PHOSPHATASE INHIBITORS.

摘要

Use of a compound of general formula (I) (I) in which: R 1 represents a hydrogen atom or an alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, - (CH2) -XY, (CH2) -Z-NR5R6 or a -CHR35R36 radical in which R35 and R36 form, together with the carbon atom that carries them, an indanyl or tetralinyl radical, or also R35 and R36 form, together with the carbon atom that carries them, a saturated heterocycle that counts 5 to 7 members and 1 to 2 heteroatoms chosen from O, N and S, the nitrogen atoms of said heterocycle being optionally substituted with radicals chosen between the alkyl radicals and the benzyl radical, which may also represent R1, when W represents O, furthermore a carbocyclic aryl radical optionally substituted 1 to 3 times with substituents independently selected from a halogen atom and an alkyl, haloalkyl or alkoxy radical, X representing a bond or a linear or branched alkylene radical which counts from 1 to 5 carbon atoms, representing Y a saturated carbon cyclic system that counts from 1 to 3 independently condensed cycles chosen between the cycles of 3 to 7 members, or representing Y a saturated heterocycle that counts from 1 to 2 heteroatoms independently chosen from O, N and S and joined to the radical X by a member N or CH, said heterocycle counting on the other hand from 2 to 6 supplementary members independently chosen from -CHR7-, -CO-, -NR8-, -O- and -S-, R7 representing a hydrogen atom or an alkyl radical and R8 representing a hydrogen atom or an alkyl or aralkyl radical, or also representing Y a carbocyclic or heterocyclic aryl radical optionally substituted 1 to 3 times with independently selected substituents from the group consisting of a halogen atom, an alkyl radical, a haloalkyl radical, an alkoxy radical, a haloalkoxy radical, a hydroxy radical, a nitro radical, a cyan radical or, the phenyl radical, an SO2NHR9 radical and an NR10R11 radical, R9 representing a hydrogen atom or an alkyl or phenyl radical, and independently representing R10 and R11 alkyl radicals, Z representing a linear or branched alkylene radical or bond that has 1 to 5 carbon atoms, R5 and R6 being independently selected from a hydrogen atom, an alkyl, aralkyl or - (CH2) n-OH radical in which n represents an integer from 1 to 6.