AVIAN CELL LINES DERIVED FROM PRIMORDIAL GERM CELLS USEFUL FOR THE PRODUCTION OF SUBSTANCES OF INTEREST

摘要

The present invention relates to a method for producing avian cell lines derived from PGC or PGC derived EG, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or non-adherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the use of such cell lines for the production of substances of interest, mainly viral vaccines and recombinant proteins.