3H,11H-OXAZOLO3',4':1,2PYRIDO3,4-BINDOLE DERIVATIVES AND THERAPEUTIC USE THEREOF

摘要

The present invention relates to a 3H,11H-oxazolo[3',4':1,2]pyrido-[3,4-5b]indole derivative of general formula (I), in which R1 is a hydrogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group; R2 is a hydrogen atom or a C1-C6 alkyl group; the dashed line between positions 1 and 11b of the ring is absent or is a bond; R3 is a hydrogen atom, a C1-C6 alkyl group or a phenyl group, the phenyl group being optionally substituted with a halogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group, and formula (II) is formula (III) in which R4 is a hydrogen atom, a C1-C6 alkyl group or a phenyl group, the phenyl group being optionally substituted with a halogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group, or R3 is absent and formula (II) is formula (IV); or mixtures thereof, or pharmaceutically acceptable addition salts thereof, or isomers, enantiomers and diastereoisomers thereof or mixtures thereof. It also relates to a process for preparing this compound, to a pharmaceutical or cosmetic composition containing it and to the therapeutic use thereof, in particular as a hypnotic.