RGD POLYPEPTIDE GRAFTED POLY (GLYCOLIC ACID-L-LYSINE-L-LACTIC ACID) / β-TRICALCIUM PHOSPHATE COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF

摘要

An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β-tricalcium phosphate composite material is made up of β-tricalcium phosphate particles and RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass ratio of 1:10~1:100, wherein the β-tricalcium phosphate particles are uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) matrix. The preparation method includes reacting poly (glycolic acid-L-lysine-L-lactic acid) with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence) to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid), and mixing the obtained RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with β-tricalcium phosphate particles. The composite material has favorite biocompatibility, cellualar affinity, biodegradability and mechanical property, and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous bone scaffold for repairing nerve tissue and bone tissue.