DISEASE MODEL ANIMAL CARRYING FOREIGN PPARa GENE TRANSFERRED THEREINTO AND USE THEREOF

摘要

The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPAR alpha in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPAR alpha activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPAR alpha using the animal.