A CONSTRAST MEDIUM COMPRISING NANOPARTICLES FORMED WITH AMPHIPHILIC POLYMER BINDING A NEAR-INFRARED FLUOROCHROME FOR DIAGNOSING TUMOR

摘要

A contrast medium comprising nanoparticles of amphiphilic polymer with a near-infrared fluorochrome is provided to diagnose small size of cancer through a non-invasive method by using near-infrared irradiation at an early stage by selectively accumulating the nanoparticles in the cancer, and selectively deliver an anti-cancer drug to the cancer cells or tissues. A contrast medium for diagnosis of tumor comprises nanoparticles of amphiphilic polymer with a near-infrared fluorochrome which are prepared by binding a hydrophilic polymer material to a hydrophobic material, wherein the hydrophilic polymer material is a biopolymer selected from dextran, chitosan, glycol chitosan, poly-L-lysine and poly-aspartic acid or a synthetic polymer selected from poly(N-2-(hydroxypropyl)methacrylamide), poly(divinyl ether-comaleic anhydride), poly(styrene-co-maleic anhydride) and poly(ethylene glycol); the hydrophobic material is a bile acid derivative such as deoxycholic acid, taurodeoxycholic acid, taurocholic acid and glycochenodeoxycholic acid or fatty acid derivative such as stearic acid and oleic acid; and the near-infrared fluorochrome is selected from fluorescein, tetramethylrhodamine, BODIPY and Alexa. A drug delivery composition comprises the nanoparticles of amphiphilic polymer with a near-infrared fluorochrome including a hydrophobic anticancer agent selected from adriamycin, cis-platin, mitomycin-C, daunomycin, 5-fluorouracil and doxolubicin. Further, the contrast medium additionally introduces radioactive rays isotope, quantum dot or MRI contrast medium.