A CONSTRAST MEDIUM COMPRISING AMPHIPHILIC HYALURONIC ACID-BASED NANOPARTICLES BINDED A NEAR-INFRARED FLUOROCHROME FOR DIAGNOSING TUMOR

摘要

The present invention relates to a cancer diagnostic contrast agent comprising amphipathic hyaluronic acid complex nanoparticles in which a near-infrared phosphor is bound, and a drug carrier for cancer treatment in which a hydrophobic anticancer agent is enclosed in the amphipathic hyaluronic acid complex nanoparticles in which the near-infrared phosphor is bound.;In the present invention, amphiphilic hyaluronic acid has a high permeability to neovascularization of cancer tissues and has high affinity with a receptor such as CD44, which is specifically expressed in cancer tissues, and thus can be selectively delivered to cancer tissues, and nanoscale in water. It is easy to accumulate in cancer tissues because it can form self-aggregates of, and the amphipathic hyaluronic acid composite nanoparticles conjugated with the near-infrared phosphor of the present invention can be applied as a contrast agent for diagnosing cancer. It can be applied as a drug carrier for cancer treatment by enclosing an anticancer agent.;Hydrophobic substances, amphiphilic hyaluronic acid, contrast agents, near-infrared phosphors, drug carriers