Antimicrobial Peptide Having Reduced Hemolytic Activity

摘要

The present invention is effective to be, more particularly, silk transformed antimicrobial peptide of some amino acids of the halo when Dean isolated from body fluid cells of sea squirts mutant was significantly improve the cell hemolytic activity antimicrobial peptide and the antimicrobial peptide of the antimicrobial peptide It relates to an antimicrobial agent containing as an ingredient. Antimicrobial peptides of the present invention is not only excellent in resistance to gram-positive and gram-negative bacteria, especially antibiotic resistant bacteria and the hemolytic activity on human cells is significantly reduced, also because the very excellent stability in serum, reduced side effects It can be useful as a new peptide antibiotics. ; Antimicrobial peptides, silk sea squirts, cell hemolytic activity