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ENHANCED VIRUS OR GENE DELIVERY USING PROTEOLIPOSOME FOR THERAPEUTICS
ENHANCED VIRUS OR GENE DELIVERY USING PROTEOLIPOSOME FOR THERAPEUTICS
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机译:使用脂蛋白体疗法治疗病毒或基因的能力增强
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摘要
A proteoliposome is provided to maximize the solubility and the stability of an adenovirus by forming the same using a wild type-proapolipoprotein A-I(WT-proapoA-I) or a variant protein thereof(V156K-proapoA-I), thereby delivering genes with high efficiency and maximizing the therapeutic effect. A proteoliposome including phospholipids and proteins such as cholesterol is characterized in that the protein is a variant of SEQ ID : NO. 6 where the 156th valine of an apolipoprotein A-I in a pro-apolipoprotein A-I of SEQ ID : NO. 1 or a pro-apolipoprotein is substituted with lysine. A gene delivery system is characterized in that a virus such as an adenovirus exists in the proteoliposome.
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机译:通过使用野生型脂蛋白AI(WT-proapoA-I)或其变体蛋白(V156K-proapoA-I)形成腺病毒,可以提供一种蛋白脂质体,以最大程度地提高腺病毒的溶解度和稳定性。效率并最大化治疗效果。包括磷脂和蛋白质例如胆固醇的蛋白脂质体的特征在于该蛋白质是SEQ ID NO:1的变体。图6中,载脂蛋白A-I中载脂蛋白A-I的第156个缬氨酸的SEQ ID NO:1。 1或载脂蛋白原被赖氨酸取代。基因传递系统的特征在于蛋白脂质体中存在病毒,例如腺病毒。
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