Therapeutic effects of intratumoral injection with adenovirus carrying IL-2 gene or TNF-α gene on hepatoma-bearing mice

摘要

Tumor necrosis factor α (TNFα) and interleukin 2(IL-2) are cytokines that possess potent antitumor andimmunomodulatory activity such as enhancing monocyte-macrophage and neutrophil cytotoxic activities,increasing T cell proliferation and IL-2 receptorexpression and augmenting cytotoxicity of cytotoxic Tlymphocyte. To investigate the therapeutic effect of thedirect cytokine gene transfer, recombinant