Derivatives of 4,6-dimethyl-2,3-dihydro-1H-pyrazolo 4,3-c pyridin-3-ONES AND 2,6-DIMETHYL-4-PHENYL-GIDRAZINONIKOTINOVYH acids as intermediates for their synthesis, have antidepressant and anxiolytic activity

摘要

1. derivatives of 4.6 - dimethyl - 2.3 - u0434u0438u0433u0438u0434u0440u043e - 1u043d - 4.3 - u043fu0438u0440u0430u0437u043eu043bu043e [with] pyridine, 3 - u043eu043du043eu0432 common formula;where the ia - r = cl;;the connection Iu0431 - r = COOC2H5,;with u0430u043du0442u0438u0434u0435u043fu0440u0435u0441u0441u0430u043du0442u043du043eu0439 and u0430u043du043au0441u0438u043eu043bu0438u0442u0438u0447u0435u0441u043au043eu0439 activity.;2. connection for 1, u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u044eu0449u0435u0435 a 4.6 - dimethyl - 2 - (u043fu0430u0440u0430u0445u043bu043eu0440u0444u0435u043du0438u043b) - 2.3 - u0434u0438u0433u0438u0434u0440u043e - 1u043d - 4.3 - u043fu0438u0440u0430u0437u043eu043bu043e [with] pyridine - 3 -, hydrochloride (ia).;3. u044du0442u0438u043bu043eu0432u044bu0435 esters 2.6 - dimethyl - (4 - (a - r - u0444u0435u043du0438u043bu0433u0438u0434u0440u0430u0437u0438u043du043e) nicotine acid of general formula;where compound iia - r = cl;;the connection IIu0431 - r = COOC2H5,;intermediate substances in the synthesis of compounds ia, Iu0431.;4. u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 on p.3 with u0430u043du0442u0438u0434u0435u043fu0440u0435u0441u0441u0430u043du0442u043du043eu0439 and u0430u043du043au0441u0438u043eu043bu0438u0442u0438u0447u0435u0441u043au043eu0439 activity.;5. pharmaceutical compositions containing as the active ingredient compound ia, excipients and u0444u0430u0440u043cu0430u0446u0435u0432u0442u0438u0447u0435u0441u043au0438 acceptable carrier.