HUMAN MONOCLONAL ANTIBODIES TO RECEPTOR OF EPIDERMAL GROWTH FACTOR (EGFR), METHOD OF THEIR PREPARATION AND USAGE, HYBRIDOME, TRANSFECTOME, TRANSGENE ANIMAL, EXPRESSION VECTOR

摘要

FIELD: medicine; pharmacology.;SUBSTANCE: allocated human monoclonal antibodies which specifically bind a receptor of the epidermal growth factor (EGFR), and also corresponding compositions on the basis of antibodies and a biospecific molecule are described. Human antibodies can be received with use of the transgenic mouse capable to formation of set of isotypes of human monoclonal antibodies by recombination V-D-J and switching of isotypes. The pharmaceutical compositions containing human antibodies for treatment or prevention of diseases, mediated by expression EGFR, the transgenic animals distinct from a human, the specified expressing antibodies, hybridomes and transfectomes which produce human antibodies are also presented. Ways of therapy and diagnostics of the diseases mediated by expression EGFR, with use of human antibodies or their antigen-binding of fragments, and also methods of growth suppression of the cells expressing EGFR, and an induction of cytolysis of the specified cells are described.;EFFECT: invention allows obtaining therapeutic and diagnostic preparations of antibodies with improved properties.;53 cl, 22 dwg, 4 tbl, 11 ex