NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE BEARING AS SUBSTITUENT GROUP PHENYL GROUP HAVING SULFONIC ESTER OR SULFONAMIDE STRUCTURE INTRODUCED THEREINTO AND EXHIBITING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY

摘要

PPROBLEM TO BE SOLVED: To provide a novel 1,2,3,4-tetrahydroquinoxaline derivative or a salt thereof that bears, as a substituent group, a phenyl group having a sulfonic ester or sulfonamide structure introduced thereinto, and a medicinal composition. PSOLUTION: The compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor modulator. In the formula, RSP1/SP, RSP2/SP, RSP3/SP, RSP4/SP, RSP5/SP, RSP6/SPand RSP7/SPare each a hydrogen atom, a lower alkyl group or the like; W and X are each an oxygen atom, a sulfur atom or the like; Y is a lower alkylene group or the like; Z is an oxygen atom, a sulfur atom, NRSP9/SP, OCO or OSOSB2/SB; and RSP9/SPis a hydrogen atom, a lower alkyl group or the like. PCOPYRIGHT: (C)2009,JPO&INPIT