New 1,2,3,4-tetrahydroquinoxaline derivative having as a substituent a phenyl group having a structure of sulfonic acid ester or amide structure introduced sulfonic acid therein and having a binding activity to the glucocorticoid receptor

摘要

A compound represented by the following general formula (1) or a pharmaceutically acceptable salt delmismo: wherein in the general formula (1), R1 represents a straight or branched chain having 1 to 8 carbon atoms, one grupocicloalquilo that having 3 to 8 carbon atoms, an aryl group, a heterocyclic group or an aralkyl group, in the case where R1 is a straight or branched chain having 1 to 8 carbon atoms, I elgrupo alkyl straight or branched chain having 1 to 8 carbon atoms may have one or more gruposelegidos between a halogen atom, a heterocyclic group, a carboxy group, a group formed by replacing elátomo hydrogen of a formyl group with a group formed by replacing the a hydrogen atom grupohidroxi with an alkyl group of straight or branched chain having 1 to 8 carbon atoms, a group formadoreemplazando one or two hydrogen atoms of an amino group with an alkyl group of oramificada straight chain having 1 to 8 carbon atoms, a group formed by replacing either one or both dehidrógeno atoms of an amino group with an alkyl straight or branched chain having 1 to 8 decarbono atoms substituted with a group formed by replacing either one or both hydrogen atoms of a grupoamino with an alkyl group of straight or branched chain having 1 to 8 carbon atoms and a group formadoreemplazando one or both hydrogen atoms of an amino group with alkyl group oramificada straight chain having 1 to 8 carbon atoms substituted with an aryl group as a substituent;