MOUSE UNABLE TO EXPRESS FUNCTIONAL alpha-4 INTEGRIN PROTEIN, METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR alpha-4 INTEGRIN PROTEIN ANTAGONIST ACTIVITY AND GENETIC MARKER FOR EVALUATING EFFICACY OF MODULATORS OF SIGNALING ACTIVITY OF VLA-4 RECEPTOR

摘要

PPROBLEM TO BE SOLVED: To provide a method for assaying an agent for potential -4 integrin protein antagonist activity. PSOLUTION: A potential antagonist of the activity of -4 integrin protein activity is indicated by detecting that the level of a genetic marker measured in a wild type mouse to which an agent is administered relative to the level of the genetic marker measured in a control wild type mouse is modulated. PCOPYRIGHT: (C)2009,JPO&INPIT