FIBROCYTE GROWTH FACTOR SUSTAINED-RELEASE BIOMATERIAL

摘要

PROBLEM TO BE SOLVED: To solve a problem that when implanting a biomaterial in a living body, fibrocyte growth factor (FGF-2) is effective for promoting its fixing and bonding with peripheral tissues such as a bone and a skin, however, materials sustainably releasing an appropriate amount of FGF-2 for tissue regeneration having activity, to an implanted site of the biomaterial for a long time are limited to organic materials with biodegradability so far, even if covering the biomaterial, the FGF-2 may be peeled off in the implantation due to the difference in the mechanical strength and prevents the direct contact between the biomaterial and the peripheral tissue and it is not always optimal for the promotion of the fixing and bonding.;SOLUTION: Immersion liquid is prepared by dissolving FGF-2 in calcium phosphate supersaturated solution prepared by mixing three types of more medical infusions, and a composite layer of FGF-2 and low-crystalline apatite is deposited on a biomaterial surface formed of anodized titanium or hydroxyapatite. The thickness of the layer and FGF-2 content can be controlled by changing the solution composition and the possibility of peeling when implanted is low due to direct formation thereof on the biomaterial surface.;COPYRIGHT: (C)2009,JPO&INPIT