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Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds
Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds
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机译:生产温度诱导的肿瘤细胞裂解物用作免疫原性化合物的方法
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摘要
The present invention relates to a process for the production of an immunogenic compound comprising inducing necrosis by temperature in tumor cells and lysing said necrotic tumor cells so as to obtain a lysate. Furthermore, the invention provides a method for the production of a pharmaceutical composition. Additionally, the invention relates to a pharmaceutical composition comprising a lysate obtainable by the aforementioned process. Moreover, methods and uses for vaccination against cancers, tumorous diseases, infections and/or autoimmune diseases comprising administering the cell lysates of the invention or dendritic cells loaded with the cell lysate loaded to an individual are provided.
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