Composition for treating nicotine dependence which comprises at least an antagonist of nicotinic acetylcholine receptor alpha 4 Beta 3 and at least a metabolite of nicotine and its use in preparing Medicine

摘要

Composition for treating nicotine dependence which comprises at least a nicotinic receptor antagonist alfa3beta4 and at least a metabolite of nicotine. The nicotinic receptor antagonist alfa3beta4 is selected from the group consisting of mecamylamine, 18 - methoxy coronaridina, bupropion, dextromethorphan and dextrorphan, and their pharmaceutically acceptable Salts.The metabolite of nicotine is selected from the group consisting norcotinina, cotinine, nornicotine, N - N - Oxide, oxide of nicotine, cotinine, 3 - and 5 - hidroxicotinina hidroxicotinina and pharmaceutically acceptable salts thereof. The cotinine dose varies from about 0.01 mg / kg to approximately 100 mg / kg body weight, per dose.Use of composition in preparing Medicine useful to reduce the symptoms of nicotine withdrawal and / or tobacco use.