Composition comprising a) at least a3beta4 nicotinic receptor antagonist; and b) at least a nicotine metabolite; and use to reduce the symptoms of nicotine withdrawal and / or useTobacco.

摘要

Compositions useful for treating an individual with nicotine dependence comprising a combination of an 34 nicotinic receptor antagonist and a nicotine metabolite are disclosed. More particularly, compositions comprising cotinine or a pharmaceutically acceptable salt thereof are disclosed. Methods of alleviating nicotine withdrawal symptoms and/or tobacco usage by administration of these compositions are also disclosed.