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A method for determining the enantiomeric purity of darifenacin and Intermediate
A method for determining the enantiomeric purity of darifenacin and Intermediate
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机译:一种测定达利福星及其中间体对映体纯度的方法
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摘要
This also refers to a method for preparing Pure compounds using darifenacin enantiomu00e9ricamente starting enantiomu00e9ricamente Cigars were previously differentiated and quantified according to the method of the present.Claim 1: a method to determine the enantiomeric purity of a compound of formula (1) or a Salt thereof,And where is Hydrogen or a Substituent of the formula (2) comprising: a) preparing a sample comprising a compound of formula (1); (b) to introduce the sample into a column of High Performance Liquid Chromatography comprising a Chiral stationary phase can separate enantiomer Of the compound of formula (1),Where the Enantiomers of the compound of formula (1) are compounds of the formula (3) and (4) or salts thereof: (c) sample elute the column with a Mobile Phase using chromatographic conditions; (d) to identify the respective Retention Times of the Enantiomers of formula (3) and (4)) Or salts thereof; and (e) to compare the areas of the Peaks associated with Retention Times dAnd the enantiomers (3) and (4) Quantifying the enantiomers, and to determine the enantiomeric purity of a compound of formula (1).
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