Immunogenic formulation, because it comprises a recombinant attenuated strain of Mycobacterium, preferably recombinant Strain Bacillus of Calmette and Guerin (BCG), which expresses at least one Protein or immunogenic Fragment of respiratory syncytial virus (RSV) in a saline solution suitable for u

摘要

The immunogenic Fragment of strains of RSV RSV subtype a and subtype B from Proteins, NS1, ns2, N, P, M, sh, m2 (ORF1), m2 (ORF2), L, F or g.The genetic material encoding these Proteins or Fragments is inserted in the Genome of BCG or so extracromosomal in one or several copies, whose expression is controlled by endogenous or exogenous promoters of BCG, constituted or inducible.Immunogenic viral Proteins or Fragments can be expressed in soluble Form by BCG - or cytoplasmic, secreted extracellularly as Proteins bound to Cell Membrane. The preparation may also contain combinations of the formulations described above.The formulation can be stabilized by lyophilization (Range between Conservation and 25sc 4SC) or temperature (- 80sc) in Saline buffer to be stored prior to use.Claim 1: immunogenic formulation that confers protection against infection or disease caused by Respiratory syncytial virus which comprises recombinant attenuated strain of Mycobacterium, preferably the strain Bacillus of Calmette and Guerin (BCG), at a concentration Among 104 - 109 bacteriaThat is at least an immunogenic Protein or Fragment of the Respiratory syncytial virus (RSV), a pharmaceutically acceptable Salt Buffer Solution.