Oral, immediate release formulation in solid form for prophylaxis and/or treatment of thrombo-embolism and process for preparing thereof

摘要

In the present invention, there is disclosed an oral immediate release formulation in solid form containing: (a) a low molecular weight, peptide-based thrombin inhibitor having pH dependent solubility and having a particle size of less than 300 microns; and (b) a combination of microcrystalline cellulose and sodium starch glycolate in an amount higher than 35 percent by weight of the formulation. There is also disclosed a process for preparing such formulation, further medicinal use of a combination of the microcrystalline cellulose and sodium starch glycolate for the preparation of the formulation as well as the formulation for prophylaxis and/or treatment of thrombo-embolism.