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An isolated Atomoxetine impurity, method of producing Atomoxetine impurities and their use as reference standards
An isolated Atomoxetine impurity, method of producing Atomoxetine impurities and their use as reference standards
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机译:分离的阿托西汀杂质,阿托西汀杂质的产生方法及其作为参考标准品的用途
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摘要
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(-)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water.
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