首页> 外国专利> DERIVATIVES OF BENZOAZEEPINOXYXIC ACID AND THEIR APPLICATION AS AN AGONISTS DELTA PPAR TO INCREASE HDL-C AND REDUCE LDL-C AND CHOLESTERIN

DERIVATIVES OF BENZOAZEEPINOXYXIC ACID AND THEIR APPLICATION AS AN AGONISTS DELTA PPAR TO INCREASE HDL-C AND REDUCE LDL-C AND CHOLESTERIN

机译:苯并EP庚二酸的衍生物及其作为促进ΔPPAR的激动剂的应用,可增加HDL-C并降低LDL-C和胆固醇

摘要

The present invention relates to compounds of formula (I) suitable for use as PPAR agonists. The present invention also relates to pharmaceutical compositions containing the compounds of the present invention, and methods for their use for treating one or more conditions, which include, but are not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, spastic colitis, inflammation, cataracts, cardiovascular diseases, metabolic X syndrome, hyper-LDL cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipi demyem and hypo-HDL-cholesterolemia), atherosclerosis, obesity and other disorders associated with lipid metabolism and complications of energy homeostasis.
机译:本发明涉及适合用作PPAR激动剂的式(I)化合物。本发明还涉及含有本发明化合物的药物组合物,以及用于治疗一种或多种病症的方法,所述病症包括但不限于糖尿病,肾病,神经病,视网膜病,多囊卵巢综合征,高血压。 ,缺血,中风,痉挛性结肠炎,炎症,白内障,心血管疾病,代谢X综合征,高LDL胆固醇血症,血脂异常(包括高甘油三酯血症,高胆固醇血症,混合性高脂血症和低HDL胆固醇血症),动脉粥样硬化,肥胖症和其他与疾病相关的疾病脂质代谢和能量稳态并发症。

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