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PROCESS FOR PREPARING TRAMADOL HYDROCHLORIDE AND/OR TRAMADOL MOMOHYDRATE
PROCESS FOR PREPARING TRAMADOL HYDROCHLORIDE AND/OR TRAMADOL MOMOHYDRATE
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机译:制备盐酸曲马多和/或曲马多一水合物的方法
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摘要
A process is described for the preparation of (RR,SS˜2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (hereinafter "tramadol hydrochloride"), which process comprises reacting a mixture of (RR,SS)- and (RS,SR)-2- dimethylaminomethyl-l-(3-methoxyphenyl) cyclohexanol with HCI in the presence of a catalytic amount of water. The process can be carried out in the absence of 1,4-dioxane or other category 1 carcinogenic solvent, and in one step, providing commercial advantages of simplicity, safety and purity. Tramadolhydrochloride is a known non-narcotic analgesic.
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