A STUDY ON THE INTERCALATION PROCESS OF TRAMADOL HYDROCHLORIDE IN ZnAl - NITRATE LAYERED DOUBLE HYDROXIDES

摘要

In this paper we report the preparation and characterization of new hybrid composites based on ZnAl-nitrate layered double hydroxides (ZnAlLDHs) and tramadol hydrochloride (TrH) via anionic exchange method. LDHs and their hybrid composites were studied by X-ray diffraction (XRD), FT-IR, RAMAN and energy dispersive x-ray (EDX) spectroscopy and scanning electron microscopy (SEM). The obtained results point out the presence of the Tramadol hydrochloride in the network structure of the new synthesized materials, when used for the ion exchange 0.8 g TrH for each 2g ZnAlDH. In the other cases, was observed the partial drug intercalation and a significant absorption on the surface of LDH. Considering together the analgesic activity of TrH and the biocompatibility of the LDHs, the new hybrid materials could open interesting perspectives for obtaining the drug reservoirs and controlled release systems.