PROCESS FOR PREPARING TRAMADOL HYDROCHLORIDE AND/OR TRAMADOL MOMOHYDRATE

摘要

A process is described for the preparation of (RR,SS~2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (hereinafter 'tramadol hydrochloride'), which process comprises reacting a mixture of (RR,SS)- and (RS,SR)-2-dimethylaminomethyl-l-(3-methoxyphenyl) cyclohexanol with HCI in the presence of a catalytic amount of water. The process can be carried out in the absence of 1,4-dioxane or other category 1 carcinogenic solvent, and in one step, providing commercial advantages of simplicity, safety and purity. Tramadolhydrochloride is a known non-narcotic analgesic.