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CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES
CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES
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机译:化学酶法合成他汀类药物和他汀类药物中间体的方法
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摘要
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making ß,d-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*, R*)]-2-(4-fluorophenyl)-b, d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl]-1H-pyrrole-l-heptanoic acid (atorvastatin, LIPITORTM), rosuvastatin (CRESTORTM), fluvastatin (LESCOLTM), related compounds and their intermediates.
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