首页>
外国专利>
Chemoenzymatic methods for the synthesis of statins and statin intermediates
Chemoenzymatic methods for the synthesis of statins and statin intermediates
展开▼
机译:化学酶法合成他汀类和他汀类中间体的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
展开▼