A PROCESS OF PREPARING HERBOSOMES WITH ANDROGRAPHOLIDE HAVING BETTER HEPATOPROTECTIVE ACTIVITY AND PRODUCT THEREOF.

摘要

This invention relates to Herbosomes with Andrographolide, a novel compound comprising lipophilic complexes of Andrographolide with phospholipids and the preparation of these complexes by non- conventional methods. Herbosomes are the concept of value addition to phytoconstituents to develop a specific dosage form with more therapeutic potency than using it as such, which increase the availability of the constituents for a longer time in blood and help in curing the diseases to a higher extant. This Herbosomes is a value added herbal formulation with isolated phytoconstituents having potential hepatoprotective activity. The novel compounds persisted for a longer period of time in plasma and subsequently produced prolonged significant hepatoprotective activity than the pure molecule at the same dose levels. The resulting improvement in the phramacokinetics and pharmacological parameters is such that the compound can be used advantageously in the treatment of acute or chronic liver diseases.