The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study.
展开▼
机译：本研究旨在确定对乙酰氨基酚对大鼠肝脏的损害，是通过干法或发酵法制备的MARDI生产的初榨椰子油的保肝作用。 3μg/ kg扑热息痛引起的肝损伤使每100μg体重的肝脏重量增加，表明肝损害。组织学观察还证实了由相应肝切片上炎症和坏死的存在所指示的肝损伤。有趣的是，用10 mL而不是1和5 mL / kg的两种VCO预处理大鼠显着（P <.05）减少了扑热息痛给药引起的肝损伤，这在组织学研究中得到了进一步证实。总之，VCO具有保肝作用，需要进一步深入研究。
展开▼
