Preparation of active Human lysosomal sulfatase enzymes and highly phosphorylated and its uses

摘要

Referring to a Human Recombinant human lysosomal sulfatase Enzyme Arylsulfatase a (ARSA) selected, Arylsulfatase B (arsb), iduronate-2-sulfatase (IDS) / heparin sulfamidase n-sulfatase (SGSH) - sulfatase (g6s n-acetylglucosamine and n-acetylgalactosamine 4-sulfatase (galns - 6).This Enzyme is produced by a group of end3 complementation Cho cell that expresses the sulfatase modifying factor 1 Human recombinant (SUMF1), being useful in the treatment of Mucopolysaccharidosis type VI, MLD, Hunter Syndrome, among others