Combination of progesterone receptor antagonist with nonsteroidal Antiestrogens for use in BRCA mediated Diseases

摘要

The progesterone 11b - (4-acetylene-phenyl) - 17b-hydroxy-17 - (1,1,2,2,2-pentafluoro) - estra-4,9-dien-3-ona, or derivatives or analogues thereof, are combined with at least one nonsteroidal antibiotic, And use this combination to prevent and treat diseases treated by BRCA1 or BRCA2. Nonsteroidal antibiotics that can be combined with toxicology 11b - (4-acetylene-phenyl) - 17b-hydroxi-17 - (1,1,2,2,2-pentafluoroethane) - estra-4,9-dien-3-ona include tamox phenol, raroxiphen, droloxiphen, toremiphen, lasofoxiphen, arzoxiphen, GW5638, EM-800, idoxiphen and basenon.