BRS-3 AGONISTS NOT PEPTIDIC.

摘要

Compounds of the general formula I, ** see formula ** in which they mean A1 CH or, with the proviso that A2 does not represent a bond and A3, simultaneously, means NH, also nitrogen; A2 a bond, C1-2 alkylene or, with the proviso that A1 represents CH and R2 means hydrogen, also carbonyl; A3 methylene, optionally substituted with C1-4 alkyl or C1-4 alkylcarbonylamide or, with the proviso that R2 means hydrogen or together with R1 represents a bond, also NH; R1 hydrogen or, with the proviso that A2 represents carbonyl, also amino, and R2 hydrogen, or R1 and R2 together represent a bond, provided that A2 means a bond; R3 hydrogen or methyl; Ar1 phenyl, optionally substituted 1 to 2 times with halogen or C1-4alkyl, or with C1-2 alkylene-dioxy bonded to two adjacent ring carbon atoms, pyridyl, furyl, indolyl or tetrahydro-isoquinolyl; Ar2 furyl, benzofuranyl, thienyl, benzothiophenyl, pyrrolyl or indolyl; Ar3 phenyl, optionally substituted 1 to 2 times with halogen, or pyridyl; m 0 or 1, and n 0 or 1, as well as, if necessary, their salts by the addition of physiologically acceptable acid.