Biodegradable macromolecular MRI contrast agents and methods of preparation and use thereof

摘要

Novel methods for preparing degradable macromolecular magnetic resonance imaging contrast agents are disclosed. Degradable macromolecular magnetic resonance imaging contrast agents of defined or controlled molecular weight distribution for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed. The macromolecular contrast agents disclosed in various aspects of this invention are degradable paramagnetic polydisulfide compounds which show prolonged plasma retention, and enhanced permeability and retention in various tissues, organs or tumors, but are still capable of being rapidly cleared from the body.