NUCLEIC ACID COMPOUNDS FOR INHIBITING P38 MAPK FAMILY GENE EXPRESSION AND USES THEREOF

摘要

The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing one or more p38 MAPK family gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to one or more p38 MAPK family mRNA. In addition, the meroduplex mayhave at least one uridine is a 5-methyluridine, a nucleoside is a locked nucleic acid, andoptionally other modifications, or any combination thereof. Also provided are methods of decreasing expression of one or more p38 MAPK family gene in a cell or in a subject to treat one or more p38 MAPK family-related disease.