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MODIFICATIONS OF THE HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID
MODIFICATIONS OF THE HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID
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机译:组氨酸去乙酰化抑制剂次羟丙二酸氢氧酸的改性
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摘要
The application relates to compounds of general formula (I) Ar-[CH2]m-Z1-N(Z2-R2)-Z3-[C(O)]r-[CH2]n-Y1-[C(O)]s-Y2-R1, in which the variables can take the values specified in the application. In particularly preferred individual compounds of formula (I), -Z1-N(Z2-R2)-Z3-[C(O)]r- forms an -O-NH-C(O)- or -NH-O-C(O)- group. Said compounds (I) are suitable as medicaments for the treatment of cancer diseases. The effect thereof is due to histone deacetylase inhibition.
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