GENETIC POLYMORPHISM OF N-ACETYLTRANSFERASE 2 (NAT2) AND USE IN MEDICINE.

摘要

The present invention is related to the field of Molecular and Genome Biology especially Pharmacogenomics. The invention describes the presence of new polymorphisms in gene encoding human Arylamine N-acetyltransf erase 2 (NAT2) enzyme, which is responsible for the metabolization of important drugs in the therapeutics of several diseases of several aetiologies, as well as of countless toxins and carcinogens present in food, cigarette and environment. The present invention includes methodology possible to be used in therapeutics using the polymorphisms described.