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RECOMBINANT IMMUNOTOXIN DIRECTED AGAINST THE HIV-1 GP120 ENVELOPE GLYCOPROTEIN
RECOMBINANT IMMUNOTOXIN DIRECTED AGAINST THE HIV-1 GP120 ENVELOPE GLYCOPROTEIN
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机译:针对HIV-1 GP120包膜糖蛋白的重组免疫毒素
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摘要
This invention provides an immunotoxin that specifically binds to and kills cells displaying an HIV gp120 coat protein. The immunotoxin comprises an anti-gp120 antibody directed to the conserved CD4 binding site of gp120 attached to a cytotoxin e.g. a Pseudomonas exotoxin. In one preferred embodiment the immunotoxin is a recombinantly expressed fusion protein comprising a single chain Fv region attached to a modified Pseudomonas exotoxin (3B3(Fv)-PE38).
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