USE OF DERIVATIVES OF VALPROIC ACID AND 2-VALPROENIC ACID AMIDES FOR THE TREATMENT OF MANIA IN BIPOLAR DISORDER

摘要

A method for the treatment of mania in bipolar disorder using derivatives of valproic acid and 2-valproenic acid amides having the following structures: wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3, or a compound containing a valproic or a 2-valproenic moiety, as well as pharmaceutical compositions comprising these derivatives or compounds.