首页> 外国专利> MARKER FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA, ANTIBODY, AND SCREENING METHOD OF COMPOUNDS USEFUL TO INHIBIT HEPATOCELLULAR CARCINOMA

MARKER FOR DIAGNOSIS OF HEPATOCELLULAR CARCINOMA, ANTIBODY, AND SCREENING METHOD OF COMPOUNDS USEFUL TO INHIBIT HEPATOCELLULAR CARCINOMA

机译:诊断肝细胞癌的标志物,抗体和筛选可抑制肝细胞癌的化合物的方法

摘要

A marker for diagnosis of hepatocellular carcinoma, an antibody, and a screening method for treating the hepatocellular carcinoma by using the same are provided to diagnose and treat HCC by identifying a gene cording E-FABP. A marker for diagnosis of hepatocellular carcinoma comprises (a) a polynucleotide of SEQ ID NO:1 or the substantially same sequence as the SEQ ID NO:1; (b) a polynucleotide coding proteins having the amino acid sequence of SEQ ID NO:2; (c) a polynucleotide which has the amino acid sequence in which at least one of the amino acid sequence of SEQ ID NO:2 is substituted, deleted, inserted and added, and codes the protein having the same functionality as the protein of SEQ ID NO:2; and (d) a polynucleotide which is coded with the polynucleotide mixed with the polynucleotide having the base sequence of SEQ ID NO:1 in a stringent condition, and codes the protein having the same functionality as the protein having the amino acid sequence coded with the base sequence.
机译:本发明提供了用于诊断肝细胞癌的标志物,抗体以及通过使用该抗体来治疗肝细胞癌的筛选方法,以通过鉴定E-FABP基因来诊断和治疗HCC。用于诊断肝细胞癌的标记物包括:(a)SEQ ID NO:1或与SEQ ID NO:1基本相同的序列的多核苷酸; (b)编码具有SEQ ID NO:2的氨基酸序列的蛋白质的多核苷酸; (c)一种多核苷酸,其具有其中SEQ ID NO:2的氨基酸序列中的至少一个被取代,缺失,插入和添加的氨基酸序列,并编码具有与SEQ ID NO:1的蛋白质相同的功能的蛋白质。 NO:2; (d)一种多核苷酸,其在严格条件下与与具有SEQ ID NO:1的碱基序列的多核苷酸混合的多核苷酸编码,并编码与具有由该序列编码的氨基酸序列的蛋白质相同功能的蛋白质。基本序列。

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