PYRIDINE 2,3-d PYRIMIDINE DERIVATIVES AS SELECTIVE KDR AND FGFR INHIBITORS

摘要

FIELD: chemistry, pharmaceutics.;SUBSTANCE: invention relates to novel derivatives of pyridine [2,3-d] pyrimidine of general formula (I) and their pharmaceutically acceptable salts, which possess properties of KDR and FGFR inhibitors. Compounds can be applied to produce medications for treatment of cancer, for instance, of mammary gland, large intestine, lungs and prostate gland. In general formula (I) , Ar and Ar' independently on each other are selected from group that includes phenyl; phenyl substituted with 1-3 substituents selected from group C₁-C₄alkyl, hydroxy, halogen, halogen-substituted C₁-C₄alkyl, C₁-C₄alkoxy; 6-member nitrogen-containing heteroaryl and 6-member nitrogen-containing heteroaryl substituted with C₁-C₄alkoxygroup, on condition that Ar standing for heteroaryl does not represent 2-pyridyl, and standing for substituted heteroaryl does not represent substituted 2-pyridyl, R¹ is selected from group including phenyl, C₁-C₁₀alkyl, C₁-C₁₀alkyl independently containing substituents selected from group that includes phenyl, C₃-C₆cycloalkyl. Invention also relates to intermediate compounds for compounds of general formula (I) and to pharmaceutical compositions.;EFFECT: obtaining derivatives and their pharmaceutically acceptable salts which possess properties of selective KDR and FGFR inhibitors.;21 cl, 2 tbl, 20 ex