A method for the preparation of precursors for l - 2 - 18f fluorine - phenylalanine and - 18f fluorine - l - meta - tyrosine and their α - methylated derivatives, precursor, with the result e a method for the production of l - 2 - 18f fluorine - phenylalanine and 6 - 18f fluorine l - meta - tyrosine and their α - methylated derivatives from the precursor

摘要

The present invention relates to a process for the preparation of precursors for 2-[¹⁸F] fluorine - phenylalanine and 6-[¹⁸F] fluorine - l - meta - tyrosine and their α - methylated derivatives, the precursor, as well as a process for the production of 2-[¹⁸F] fluorine - phenylalanine and 6-[¹⁸F] fluorine - l - meta - tyrosine and their α - methylated derivatives from the precursor.According to the invention, a compound of formula (3) getellt available, the automated synthesis of l - 3,4 - dihydroxy - 6-[¹⁸F] fluorine - phenylalanine and 6-[¹⁸F] fluorine - l - meta - tyrosine permits. The enantiomers unit of the product is ≧ 98%.