METHOD FOR PRODUCING PRECURSORS FOR L-2-18FFLUOROPHENYLALANINE AND 6-18FFLUORO-L--META-TYROSINE AND THE ALPHA -METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2-18FFLUOROPHENYLALANINE AND 6-18FFLUORO-L-META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR

摘要

The invention relates to a method for producing precursors for L-2-[18F]fluorophenylalanine and 6-[18F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof, said precursor, and a method for producing L-2-[18F]fluorophenylalanine and 2-[18F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof from the precursor. According to the invention, a compound of formula (3) is used to enable an automated synthesis of L-3,4-dihydroxy-6-[18F]fluorophenylalanine and 6-[18F]fluoro-L-meta-tyrosine. The enantiomer purity of the product amounts to ≥ 98%.