CHIRAL LIGANDS OF N-HETEROCYCLIC CARBENE TYPE FOR ASYMMETRIC CATALYSIS.

摘要

Compounds of formula (I) or formula (II) wherein X is an anion; n 1 = 0, 1, 2; n 2 = 1 to 4; R 1 is a C1 to C6 alkyl, or an optionally substituted C5 or C6 cycloalkyl, or a C1 to C6 perhaloalkyl; R 2 is a C1 to C8 alkyl, or an optionally substituted C5 or C6 cycloalkyl, or an optionally substituted aryl, or an optionally substituted naphthyl, or a -CH3-n (Aryl) n radical with n = 1 to 3, or a radical -CH (R) Z where R is hydrogen, or a C1 to C6 alkyl, or an optionally substituted C5 or C6 cycloalkyl, or a C1 to C6 perhaloalkyl; Z is a C1 to C8 alkyl, or a C5 or C6 cycloalkyl, or a radical of the formula: Y is hydrogen, or an OR 9, or SR 10, or a P (R 11) 2, or halogen or OSO2R 12; n 3 = 1 to 4; R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, R 11, R 12, independently, are H, or C1-C6 alkyl, or C1-C6 perhaloalkyl, or optionally substituted C5 or C6 cycloalkyl or aryl; R 3 and R 4 on the one hand and R 6 and R 7 on the other hand can form a ring with 3, 4, 5, 6 and 7 links; R 5 and R 8 can independently form a 6-membered aromatic ring.