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Adenovirus having a mutation in the endoplasmic reticulum retention domain of E3-19K protein and its use in cancer therapy
Adenovirus having a mutation in the endoplasmic reticulum retention domain of E3-19K protein and its use in cancer therapy
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机译:E3-19K蛋白内质网保留结构域中具有突变的腺病毒及其在癌症治疗中的应用
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摘要
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.
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