ADENOVIRUS WITH MUTATIONS IN THE ENDOPLASMIC RETICULUM RETENTION DOMAIN OF THE E3-19K PROTEIN AND THEIR USE IN CANCER TREATMENT

摘要

The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.