Composition and method for evaluating the P4502C19 cytochrome isozyme activity by using the breath test

摘要

The present invention generally by by breath ^analysis, to determine the relative amount of ¹³ CO ₂ the subject is discharged when administered orally or intravenously administered ¹³ C-labeled cytochrome P450 2C19 isozymes (CYP2C19) substrate compound in a mammalian subject individual relates to a method for evaluation as well as determine the CYP2C19-related metabolic capacity. By evaluating the enzymatic activity of CYP2C19 in a subject using the metabolite ¹³ CO ₂ in the breath, the phenotyping of the individual subject, and the selection of drug, the optimal dose, and the present invention, the drug administration and is useful as in vivo analysis noninvasive seeking timing. [Selection] Figure Figure 1