The caffeine breath test: A less invasive method to measure cytochrome P450-1A activity in birds.

摘要

ytochrome P450-1A activity is often used as a biomarker of exposure of wildlife to planar polychlorinated diaromatic hydrocarbons, and is usually measured ex vivo in liver tissue. The purpose of this study was to develop a less invasive breath test to measure P450-1A activity in birds. This would allow an assessment of P450-1A activity without the need to kill birds, and would allow measurement on the same individual over time. Caffeine is specifically metabolized by P450-1A. The caffeine breath test (CBT) was performed by injecting